'Exes & Ohs' centers around the dating life of Jennifer, a lesbian documentary filmmaker with a vivid fantasy life and a floundering career. Jennifer is looking for Ms. Right but must navigate the rules of lesbian dating life, most of which she learns the hard way. Fortunately, her friends are there to help: Sam, a commitment-phobe who flips women faster than real estate; Chris and Kris, a lesbian couple expanding both their pet accessory business and their family; and Crutch, a young musician who wants to be taken seriously but still has some growing up to do.

The new, uninhibited Jennifer tells everyone what she really thinks, including her ex-girlfriend Sienna. Meanwhile Sam gives into therapy and Kris gets inseminated.

Katie plays the character of Olivia.